During an INMEST treatment in a dry eye study, one patient reported a surprisingly strong improvement in symptoms related to Restless Legs Syndrome (RLS). The patient independently reached out to the Swedish RLS association to share the experience. RLS is estimated to affect around 10% of women and 5% of men, yet it remains relatively unknown and lacks effective treatment options.

This observation has caught the attention of researchers at Uppsala University Hospital, with whom the foundation is now in contact. Together, they are exploring the possibility of launching a new study on RLS. It’s not uncommon for new therapeutic applications to be identified during studies treating other conditions.

INMEST is believed to influence the body’s inflammatory and neurological systems and is still undergoing clinical evaluation. Previous studies have shown promising effects in conditions such as ME/CFS, Sjögren’s syndrome, and COPD. While the mechanism behind the observed RLS improvement is not yet understood, hypotheses include modulation of the dopamine system or reduction of oxidative stress — both relevant to RLS.

The foundation sees this as an opportunity to investigate further. Cases like this highlight the importance of continued research in areas where current medical care offers limited solutions.